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雷公藤甲素/雷公藤多甙/雷公藤內(nèi)酯醇/雷藤素甲

Triptolide

產(chǎn)品編號(hào):WKQ-0000333 CAS No.:38748-32-2 純度:HPLC≥98% 分子式:C20H24O6

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  • 基礎(chǔ)信息
  • 產(chǎn)品詳情
  • 相關(guān)文獻(xiàn)
基本信息
英文名稱 Triptolide
中文名稱雷公藤甲素/雷公藤多甙/雷公藤內(nèi)酯醇/雷藤素甲
CAS號(hào)38748-32-2
分子式C20H24O6
分子量360.4
外觀 白色粉末
熔點(diǎn)226-227 °C
沸點(diǎn)601.7±55.0 °C | Condition: Press: 760 Torr
酸度系數(shù)pKa14.25±0.60 | Condition: Most Acidic Temp: 25 °C
產(chǎn)品詳情

WKQ-0000333

中文名稱:雷公藤甲素

中文別名:雷公藤多甙;雷公藤內(nèi)酯醇;雷藤素甲

英文名稱:Triptolide

英文別名:Triptolide;(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one;(-)-Triptolide;NSC 163062;PG 490;Triptolid;[3bS-(3bα,4aα,5aR*,6β,6aβ,7aβ,7bα,8aR*,8bβ)]-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one;

分子式:C20H24O6

分子量:360.40

CAS號(hào):38748-32-2

純度:HPLC≥98%

熔點(diǎn):226-227 °C

沸點(diǎn):601.7±55.0 °C | Condition: Press: 760 Torr

密度:1.48±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr

酸系度數(shù):14.25±0.60 | Condition: Most Acidic Temp: 25 °C

儲(chǔ)存條件:-20℃,干燥、避光、密封

規(guī)格:5mg10mg20mg50mg100mg500mg1g2g等應(yīng)客戶需求包裝

供應(yīng)單位:四川省維克奇生物科技有限公司

供應(yīng)電話:028-81700200/4008005713

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相關(guān)文獻(xiàn)
Identification and comparison of compounds in commercial Tripterygium wilfordii genus preparations with HPLC-QTOF/MS based on molecular networking and multivariate statistical analysis
來(lái)源:SCI:JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 作者:Ge Xun 備注:影響因子:3.571
引用描述

Spectra grade methanol and acetonitrile were purchased from Tedia (Fairfeild, USA). HPLC-grade formic acid was purchased from Kermel Chemical Reagent Co., Ltd. (Tianjin, China). Purified water was purchased from Wahaha (Zhejiang, Hangzhou, China). The reference standards triptolide, triptonide, triptophenolide, tripterifordin, wilforgine, wilforine, celastrol, demethylzeylasteral, wilforlide A, and pristimerin were purchased from Sichuan Weikeqi Biological Technology Co., Ltd. (Sichuan, China), and their purity was greater than 98%. Commercial Tripterygium glycosides tablets (TGT) were purchased from 13 factories (A-J), three batches of commercial Tripterygium wilfordii tablets (TWT) were from one factory (K), six different batches of commercial Tripterygium hypoglaucum hutch tablets (THHT) were purchased from two factories (L and M).

Hyperoside, a natural flavonoid compound, attenuates Triptolide-induced testicular damage by activating the Keap1-Nrf2 and SIRT1-PGC1α signalling pathway
來(lái)源:SCI:JOURNAL OF PHARMACY AND PHARMACOLOGY 作者:Wang Yucheng 備注:影響因子:4.81
引用描述

Hyp (purity>99%) and TP (purity>99%) were acquired via Sichuan Weikeqi Biological Technology Co., Ltd. TP was dissolved in DMSO and then diluted 20 times with normal saline for intraperitoneal injection.

Synchronous Investigation of the Mechanism and Substance Basis of Tripterygium Glycosides Tablets on Anti-rheumatoid Arthritis and Hepatotoxicity
來(lái)源:SCI:APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 作者:Qian, Qi 備注:影響因子:3.094
引用描述

Formic acid was HPLC grade obtained from Fisher (Fair Lawn, NJ, USA). Triptolide (Batch No. wkq18062706, purity?≥?98%), triptonide (Batch No. wkq18030812, purity?≥?98%), triptophenolide (Batch No. wkq18031301), wilforgine (Batch No. wkq18051009, purity?≥?98%), wilforine (Batch No. wkq18080604, purity?≥?98%), demethylzeylasteral (Batch No. wkq18031201, purity?≥?98%), and celastrol (Batch No. wkq18042604, purity?≥?98%) were purchased from Sichuan Weikeqi Biological Technology, Co., Ltd. (Sichuan, P.R. China).

Triptolide inhibits human immunodeficiency virus type 1 replication by promoting proteasomal degradation of Tat protein
來(lái)源:SCI:Retrovirology 作者:Wan, Zhitao 備注:影響因子:4.767
引用描述

The compounds isolated from Chinese traditional herbs for the anti-HIV-1 drug screen were purchased from Sichuan Weikeqi Biological Technology Co., Ltd., China. The purity of the compound was ≥ 98%, as was determined by high-performance liquid chromatography analysis. The compound samples were solved in dimethyl sulfoxide (DMSO) at a concentration of 50 mM.

Aucubin, a natural iridoid glucoside, attenuates oxidative stress-induced testis injury by inhibiting JNK and CHOP activation via Nrf2 up-regulation
來(lái)源:SCI:PHYTOMEDICINE 作者:Bo Ma 備注:影響因子:4.18
引用描述

DAPI 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium, MTT 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide and DMEM/F12 were obtained from Sigma (St. Louis, MO, USA). Aucubin (purity > 98%) and Triptolide (purity > 98%) were obtained from Weikeqi-Biotech Co., Ltd (Chengdu, China). The purity of Aucubin was detected using Waters alliance 2695-2998 HPLC.

Epigallocatechin-3-gallate Prevents Triptolide-Induced Hepatic Injury by Restoring the Th17/Treg Balance in Mice
來(lái)源:SCI:AMERICAN JOURNAL OF CHINESE MEDICINE 作者:Shu-Jing Yu 備注:影響因子:2.959
引用描述

Purified TP and EGCG were purchased from Sichuan Weikeqi Biological Technology Co., Ltd (Sichuan, China), their purity was verified with the HPLC method (purity

>98%) (Fig. 1). TP and EGCG were stored at 4C, prepared fresh prior to use, TP was

dissolved in a small amount of absolute ethyl alcohol, and EGCG was dissolved in a small

amount of DMSO


Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balance through Tim-3 and TLR4-MyD88-NF-κB pathway
來(lái)源:SCI:INTERNATIONAL IMMUNOPHARMACOLOGY 作者:Lian-Di Zhou 備注:影響因子:2.956
引用描述

QE (purity > 98%) and TP (purity > 98%) were obtained from Sichuan Weikeqi Biological Technology Co., Ltd. (Sichuan, China). TLR4 protein antagonist Resatorvid (TAK-242) was purchased from Shanghai ZZBIO Co., Ltd. (Shanghai, China). Antibodies against TLR4, NF-κB, Foxp3 and β-actin were purchased from Wanleibio Co., Ltd.

Simultaneous determination of seven effective components of Tripterygium glycosides in human biological matrices by ultra performance liquid chromatography–triple quadrupole mass spectrometry
來(lái)源:SCI:JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 作者:Xi Du 備注:影響因子:2.813
引用描述

Triptolide (HPLC purity 99.49%), triptophenolide (HPLC purity 99.29%), celastrol (HPLC purity 98.33%), wilforgine (HPLC purity 99.53%), wilforine (HPLC purity 99.32%) and wilfortrine (HPLC purity 99.09%) were supplied by Weikeqi Biological Technology Co., Ltd (Sichuan, China). Wilfordine (HPLC purity 98%) was purchased from ChemFaces Biochemical Co., Ltd (Wuhan, China) and irbesartan (HPLC purity 99.8%) was used as internal standard (IS) and was obtained from National Institute for Food and Drug Control (Beijing, China).

Alteration of Androgen Receptor Protein Stability by Triptolide in LNCaP Cells
來(lái)源:SCI:Medicina-Lithuania 作者:Wei Li 備注:影響因子:1.429
引用描述

Triptolide was purchased from Sichuan Weikeqi-Biotech Company (Chengdu, China); Cycloheximide (CHX) was purchased from Dalian Meilun Biotechnology (Dalian, China); Probenecid was purchased from Shanghai Aladdin Bio-Chem Technology Co., Ltd. (Shanghai, China); A23187 was purchased from BioVision, Inc. (Milpitas, CA, USA), BAPTA-AM was purchased from Selleck Chemicals

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