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雷公藤次堿/雷公藤堿/雷公藤靈/威爾福林

Wilforine

產(chǎn)品編號:WKQ-0001315 CAS No.:11088-09-8 純度:HPLC≥98% 分子式:C43H49NO18

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基本信息
英文名稱 Wilforine
中文名稱雷公藤次堿/雷公藤堿/雷公藤靈/威爾福林
CAS號11088-09-8
分子式C43H49NO18
分子量867.84
外觀
熔點(diǎn)158-163 °C
沸點(diǎn)871.5±65.0 °C | Condition: Press: 760 Torr
酸度系數(shù)pKa11.70±0.70 | Condition: Most Acidic Temp: 25 °C
產(chǎn)品詳情

WKQ-0001315

中文名稱:雷公藤次堿

中文別名:雷公藤堿;雷公藤靈;威爾福林

英文名稱:Wilforine

英文別名:Evonimine, 8-(acetyloxy)-O2-benzoyl-O2-deacetyl-8-deoxo-, (8α)-;Wilforine (8CI);(8R,9R,10R,11S,12S,13R,14R,15S,18S,21S,22S,23R)-10,13,22,23-Tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-14-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-21-hydroxy-8,18,21-trimethyl-8,11-epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17(18H)-dione;26-Deoxywilfordine;8,11-Epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17(18H)-dione, 10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-14-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-21-hydroxy-8,18,21-trimethyl-, [8R-(8R*,9R*,10R*,11S*,12S*,13R*,14R*,15S*,18S*,21S*,22S*,23R*)]-;

分子式:C43H49NO18

分子量:867.84

CAS號:11088-09-8

純度:HPLC≥98%

熔點(diǎn):158-163 °C

沸點(diǎn):871.5±65.0 °C | Condition: Press: 760 Torr

密度:1.41±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr

酸系度數(shù):11.70±0.70 | Condition: Most Acidic Temp: 25 °C

儲存條件:-20℃,干燥、避光、密封

規(guī)格:5mg10mg20mg50mg100mg500mg1g2g等應(yīng)客戶需求包裝

供應(yīng)單位:四川省維克奇生物科技有限公司

供應(yīng)電話:028-81700200/4008005713

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相關(guān)文獻(xiàn)
Identification and comparison of compounds in commercial Tripterygium wilfordii genus preparations with HPLC-QTOF/MS based on molecular networking and multivariate statistical analysis
來源:JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 作者:Ge Xun 備注:影響因子:3.571
引用描述

Spectra grade methanol and acetonitrile were purchased from Tedia (Fairfeild, USA). HPLC-grade formic acid was purchased from Kermel Chemical Reagent Co., Ltd. (Tianjin, China). Purified water was purchased from Wahaha (Zhejiang, Hangzhou, China). The reference standards triptolide, triptonide, triptophenolide, tripterifordin, wilforgine, wilforine, celastrol, demethylzeylasteral, wilforlide A, and pristimerin were purchased from Sichuan Weikeqi Biological Technology Co., Ltd. (Sichuan, China), and their purity was greater than 98%. Commercial Tripterygium glycosides tablets (TGT) were purchased from 13 factories (A-J), three batches of commercial Tripterygium wilfordii tablets (TWT) were from one factory (K), six different batches of commercial Tripterygium hypoglaucum hutch tablets (THHT) were purchased from two factories (L and M).

Differences in Multicomponent Pharmacokinetics, Tissue Distribution, and Excretion of Tripterygium Glycosides Tablets in Normal and Adriamycin-Induced Nephrotic Syndrome Rat Models and Correlations With Efficacy and Hepatotoxicity.
來源:Frontiers in Pharmacology 作者:Wei Wu 備注:影響因子:5.988
引用描述

TPL (Lot: 111,567–202,005) and irbesartan (as the IS for the MS/MS determination, Lot: 100,607–201,804) reference substances (content >99%) were obtained from National Institute for Food and Drug Control (Beijing, China). WA (Lot: wkq20040901), WFG (Lot: wkq20040804), WFT (Lot: wkq20040203), WFD (Lot: wkq20040702), and WFR (Lot: wkq20040205) reference substances (content >98%) were purchased from Sichuan Weikeqi Biological Technology Co., Ltd. (Sichuan, China). Adriamycin (ADR) hydrochloride for injection (Lot: 2007E1) was provided by Shenzhen Main Luck Pharmaceuticals Inc. (Shenzhen, China).

Synchronous Investigation of the Mechanism and Substance Basis of Tripterygium Glycosides Tablets on Anti-rheumatoid Arthritis and Hepatotoxicity
來源:SCI:APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 作者:Qian, Qi 備注:影響因子:3.094
引用描述

Formic acid was HPLC grade obtained from Fisher (Fair Lawn, NJ, USA). Triptolide (Batch No. wkq18062706, purity?≥?98%), triptonide (Batch No. wkq18030812, purity?≥?98%), triptophenolide (Batch No. wkq18031301), wilforgine (Batch No. wkq18051009, purity?≥?98%), wilforine (Batch No. wkq18080604, purity?≥?98%), demethylzeylasteral (Batch No. wkq18031201, purity?≥?98%), and celastrol (Batch No. wkq18042604, purity?≥?98%) were purchased from Sichuan Weikeqi Biological Technology, Co., Ltd. (Sichuan, P.R. China).

Wilforine, the Q-marker and PK-maker of Tripterygium glycosides tablet: Based on preparation quantitative analysis and PK-PD study
來源:SCI:PHYTOMEDICINE 作者:Xue Gao 備注:影響因子:3.61
引用描述

Wilfortrine (NO. 151128), wilforine (NO. 151218), wilforgine (NO. 150922), and wilfordine (NO. 160127) reference substances (purity? > 98%) were all purchased from Sichuan Weikeqi Biological Technology Co., Ltd., tripterygium glycosides tablet samples were purchased from local pharmaceutical stores (Tianjin, China), which were produced by four manufactures (De-en De (DND)

Simultaneous determination of seven effective components of Tripterygium glycosides in human biological matrices by ultra performance liquid chromatography–triple quadrupole mass spectrometry
來源:SCI:JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 作者:Xi Du 備注:影響因子:2.813
引用描述

Triptolide (HPLC purity 99.49%), triptophenolide (HPLC purity 99.29%), celastrol (HPLC purity 98.33%), wilforgine (HPLC purity 99.53%), wilforine (HPLC purity 99.32%) and wilfortrine (HPLC purity 99.09%) were supplied by Weikeqi Biological Technology Co., Ltd (Sichuan, China). Wilfordine (HPLC purity 98%) was purchased from ChemFaces Biochemical Co., Ltd (Wuhan, China) and irbesartan (HPLC purity 99.8%) was used as internal standard (IS) and was obtained from National Institute for Food and Drug Control (Beijing, China).

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